Saudi Journal of Gastroenterology
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Year : 2007  |  Volume : 13  |  Issue : 4  |  Page : 187-190

Lipid peroxides in patients with inflammatory bowel disease

1 Department of Physiology, Gastroenterology Unit College of Medicine, King Saud University, Riyadh, Saudi Arabia
2 Department of Medicine, Gastroenterology Unit College of Medicine, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Mohammed A Alzoghaibi
College of Medicine, Department of Physiology, King Saud University, P.O. Box 7805, Riyadh 11472
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-3767.36750

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Background/Aims: In this study, we aimed to determine the levels of malondialdehyde (MDA) in patients with inflammatory bowel disease (IBD) to investigate its contribution to tissue injury in IBD. Materials and Methods: Forty-two patients with IBD (24 cases of Crohn's disease and 18 cases of ulcerative colitis) and 38 matched healthy subjects (control group) were considered for study. MDA levels were quantified by the measurement of thiobarbituric acid reactive substances. Results: Plasma MDA levels of Crohn's disease patients were significantly higher than the control group, but not higher than the ulcerative colitis patients. Plasma MDA levels of patients with ulcerative colitis were higher than the control group but not significant. Conclusion: Increased levels of plasma MDA in IBD is an important indication of oxidative stress. Patients with Crohn's disease are more susceptible to oxidative stress than patients with ulcerative colitis.

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