Saudi Journal of Gastroenterology
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Year : 2014  |  Volume : 20  |  Issue : 4  |  Page : 241-247

Differential diagnosis of intestinal tuberculosis from Crohn's disease and primary intestinal lymphoma in China

1 Department of Gastroenterology, Renmin Hospital of Wuhan University, Hubei Province, China
2 Department of Gastroenterology, The Second People's Hospital of Wuhu, Anhhui Province, China

Correspondence Address:
Dr. Ming-Kai Chen
Department of Gastroenterology, Renmin Hospital of Wuhan University, 99 Ziyang Road, Wuhan 430060, Hubei Province
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Source of Support: This work was supported by National Natural Science Foundation of China (Key Grant No. 81170350) and Hubei Province Natural Science Fund of China (Key Grant No.2009CDB283),, Conflict of Interest: None

DOI: 10.4103/1319-3767.136979

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Background/Aims: There are many similarities and overlaps in clinical, radiological, endoscopic, and histological features among intestinal tuberculosis (ITB), Crohn's disease (CD), and primary intestinal lymphoma (PIL), and the differential diagnosis of ITB can be very challenging for clinicians. Patients and Methods: The clinical, radiologic, endoscopic, and pathological data of 213 patients were analyzed retrospectively. According to the diagnostic criteria and exclusive criteria of ITB, CD, and PIL, 83 patients were recruited and divided into three groups, including 30 cases in the ITB group, 38 cases in the CD group, and 15 cases in the PIL group, and the medical data and statistical analysis were recorded. Results : Rural patients with abdominal pain as the first symptom and with transverse ulcer and caseating granulomas were more common in the ITB group than the CD group, whereas urban patients with stool change as the first symptom, moderate or severe anemia, thickening of intestinal wall, rectal involvement, skipping distribution, prominent lymphoid aggregates, and irregular glands were more common in CD group than ITB group (P < 0.05). Young patients (age < 30 years) with fever, weakness, fatigue, abdominal mass, intestinal perforation, and emergent operation were more common in ITB group than PIL group, whereas thickening of intestinal wall, malignant lymphocytes, limited distribution, and involvement of small intestine occurred more in PIL group than ITB group (P < 0.05). Conclusion : The differential diagnosis of ITB from CD and PIL can be made by a combination of clinical manifestation, endoscopy, and pathological examinations.

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