Saudi Journal of Gastroenterology
Home About us Instructions Submission Subscribe Advertise Contact Login    Print this page  Email this page Small font sizeDefault font sizeIncrease font size 
Users Online: 455 

Table of Contents   
Year : 2014  |  Volume : 20  |  Issue : 6  |  Page : 342-349
Overlap syndromes: An emerging diagnostic and therapeutic challenge

1 Department of Biochemistry, JIPMER, Dhanvantari Nagar, Puducherry, India
2 Department of Medical Gastroenterology, Batra Hospital and Medical Research Centre, New Delhi, India

Click here for correspondence address and email

Date of Submission13-Feb-2013
Date of Acceptance26-Apr-2014
Date of Web Publication24-Nov-2014


Overlap syndrome in hepatology is emerging as a diagnostic and therapeutic challenge, which is further complicated by the present gaps in the information regarding the immunopathogenesis of these diseases. The present review represents a concise review of literature on overlap syndromes with emphasis on prevalence, etiopathogenesis, clinical presentation, diagnosis, and management of true overlap syndromes.

Keywords: Autoantibodies, autoimmune, biliary, overlap

How to cite this article:
Dhiman P, Malhotra S. Overlap syndromes: An emerging diagnostic and therapeutic challenge. Saudi J Gastroenterol 2014;20:342-9

How to cite this URL:
Dhiman P, Malhotra S. Overlap syndromes: An emerging diagnostic and therapeutic challenge. Saudi J Gastroenterol [serial online] 2014 [cited 2022 Nov 27];20:342-9. Available from:

Autoimmune liver diseases are a group of disorders characterized by aberrant, self-directed immune response on hepatocytes or cholangiocytes, subsequently leading to fibrosis and cirrhosis. The three main categories of autoimmune liver diseases are autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), each regarded as a distinct entity with constellation of specific clinical, biochemical, immunological, and histological profiles. The characteristic histological patterns are a chronic hepatitis pattern of injury with prominent plasma cells in AIH, destruction of small intrahepatic bile ducts and canals of Hering in PBC, and periductal fibrosis and inflammation involving large bile ducts with variable small duct damage in PSC. Serological findings include the presence of antimitochondrial antibody (AMA) in PBC, antinuclear antibody (ANA), anti-smooth muscle antibody (ASMA) and anti-liver kidney microsome (LKM)-1 antibody in AIH, and perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) in PSC. [1] Overlap syndrome describes variant forms of AIH and autoimmune cholangiopathies with composite hepatic and cholestatic profiles of AIH and PBC or PSC that do not fit readily into the usual diagnostic categories. [2],[3]

In addition to AIH-PBC and AIH-PSC overlap syndromes, autoimmune cholangitis (AIC; AMA negative PBC) as outlier syndrome [4] and transition from one autoimmune hepatopathy to another (e.g. PBC to AIH, [2],[5] AIH to PBC, and AIH to PSC) [6],[7] as sequential syndrome have been described. [8],[],[9],[10],[11] The term overlap syndrome should not be used when comorbidity, for example, chronic hepatitis C in a patient with PBC or sarcoidosis in a patient with PSC or hepatitis C with nonalcoholic steatohepatitis, exists. [12] The problems faced while diagnosing overlap syndromes include presence of features of AIH in many patients of PBC [mild interface hepatitis, raised immunoglobulin G (IgG)] and presence of raised immunoglobulin M (IgM) and AMAs in patients of AIH. [13],[14],[15],[16] These overlap syndromes represent a diagnostic and therapeutic challenge as no established serological, biochemical, or histological markers have been accepted equivocally. Nevertheless, it is important to recognize these clinical entities as it has important therapeutic and prognostic implications. [17] The present review represents a concise review of literature on overlap syndromes with emphasis on prevalence, etiopathogenesis, clinical presentation, diagnosis, and management of true overlap syndromes. AIC (outlier syndrome) and AIH-AIC are not described here as they represent a heterogeneous category that encompasses patients with atypical, early, or transitional features of classical disease. [18]

   Epidemiology of overlap syndromes Top

Overlap syndromes, previously thought to be a rare entity, have been the subject of various studies in the last decade. Some formal studies suggest that nearly 20% of patients with an autoimmune liver disease have, at presentation, features suggestive or characteristic of a second autoimmune liver disease, that is, they present with overlap syndrome. [19] The existence of PBC-AIH overlap was reported around 35 years back. [20] Since then, a number of PBC-AIH overlap patients have been described in genetically and environmentally different geographic areas, such as Europe, [2],[3],[21],[22],[23] Turkey, [24] United States, [25],[26] Canada, [27] Japan, [28] India, [11],[29] and China. [30] Chazouilleres et al. provided evidence for AIH-PBC overlap in 8% of 199 patients with AIH (n = 162) or PBC (n = 37) and in 9% of 130 patients with PBC. [2] A recent analysis of a smaller cohort of 82 consecutive patients with definite or probable AIH based on the revised AIH score of International Autoimmune Hepatitis Group (IAIHG) [31] found overlap with PBC in 13% of patients. [22] Another comparative study by Heurge et al. demonstrated a prevalence of 13.9% of overlap syndrome in patients of PBC and AIH (n = 115). [23]

In short, occurrence rate of overlap syndrome ranges from 5% of patients initially diagnosed as having AIH to 19% of patients initially diagnosed as having PBC. [32] Contrary to AIH-PBC overlap, AIH-PSC overlap syndromes are more common in young patients with autoimmune liver disease and may comprise 6% of patients with AIH and 8% of patients with PSC. [33],[34],[35],[36]

In a landmark 16-year prospective study conducted in Kings College, London, authors followed-up a group of 55 children with AIH. Among these children, 23 presented cholangiographic findings typical of PSC. This overlap of AIH and PSC was termed autoimmune sclerosing cholangitis (ASC). [6] In adult patients of AIH, histological changes of lymphocytic, pleomorphic, or fibrous cholangitis, concurrent inflammatory bowel disease (IBD), or failure to respond to glucocorticoids constitute indications for cholangiography. Around 41% of these patients demonstrate changes of PSC. Furthermore, 54% of patients who have PSC have histological features that support a probable or definite diagnosis of AIH. [9],[19],[32],[37] In a recent study, magnetic resonance cholangiography has demonstrated unsuspected PSC of large bile ducts in 8% of adults with AIH. [38] PBC-PSC and AIH-AIC overlap syndrome/coexistence have been described in certain case reports. [39],[40],[41],[42]

   Aih-Pbc Overlap Syndrome Top

AIH-PBC overlap syndromes are the most common ones among autoimmune hepatopathies, with a reported prevalence of 4.8-19% in PBC patients and 5-8.3% in AIH patients. [2],[25],[27],[32],[43]


Both PBC and AIH share an autoimmune pathogenesis. Lohse et al. identified human leukocyte antigen (HLA), B8;DR3;DQ2 haplotype as a risk factor for the development of AIH-PBC overlap. [3]

Preliminary studies have been done to define genetic susceptibility and immunopathogenesis in AIH-PBC overlap syndrome, though no conclusive evidence has been presented so far. [44],[45] A recent report suggests that HLA DR7 could help in differentiating the overlap syndromes from pure AIH. [46]

Clinical presentation

Simultaneous presence of features of both AIH and PBC at initial presentation is the most frequent and easily recognizable form of overlap syndrome. [17] There are reports of AIH and PBC occurring sequentially or consecutively, [10],[47],[48],[49],[50],[51],[52] or appearing after liver transplantation done for a different autoimmune hepatopathy. [53],[54],[55],[56],[57] Patient of AIH-PBC overlap presenting with fulminant hepatic failure as the initial form of presentation has also been reported. [58] Patients with features of PBC-AIH overlap have been reported to be at greater risk of developing symptomatic portal hypertension [with esophageal varices, gastrointestinal (GI) bleeding, and ascites] and having an adverse outcome (death and/or orthotopic liver transplantation). [26]

Interestingly, the reports describing AIH-PBC overlap do not discuss any specific clinical features that distinguish overlapping PBC-AIH overlap versus PBC or AIH alone, but the focus has entirely been on laboratory and histological features . [3]

Laboratory features

The biochemical features of patients with the AIH-PBC overlap syndrome include high serum levels of transaminases plus markers of cholestasis and increased levels of IgM and IgG. [52] Histologically, features of both diseases are evident, i.e. interface hepatitis and bile duct destruction. [52] The usefulness of IgG and IgM immunostaining for the distinction of AIH and PBC and their staining pattern in cases of AIH-PBC overlap syndrome have been investigated in certain studies, but no conclusive evidence has been found. [59]

Serologically, there is positivity for ANA, ASMA, and AMA. Although ANA positivity is seen in 40% of pure PBC patients also, the pattern is specific for the disease (multiple nuclear dots). [60],[61] Although a systemic and complete analysis of the serological profile of cases of AIH-PBC overlap syndrome is lacking, in a recent study, Muratori et al. compared the serological profiles of PBC (n = 120), AIH (n = 120), and AIH-PBC overlap syndrome patients (n = 15), and found a high frequency of anti-dsDNA antibodies in overlap syndrome patients (60%) compared to that in patients suffering from pure form of the disease (4% in PBC and 26% in AIH). [62]

In another report, in a small subgroup (3.9%) of 233 patients with PBC, the presence of soluble liver antigen antibodies (SLA/LP) was a marker of AIH-PBC overlap syndrome with a good response to immunosuppressive therapy, [63] although these findings were not validated by other groups. [64] Furthermore, a study of immunoreactivities of AMA against branched chain acyltransferase in the sera of patients with PBC and AIH-PBC overlap syndrome demonstrated absence of immunoreactivity against C-terminal sequences of the enzyme in overlap patients compared to those with pure forms of disease, which may serve as a marker for differentiating patients with PBC from those with overlap syndrome of PBC with AIH. [65]


To diagnose AIH-PBC overlap syndrome, there are three different proposals to date:

1. The simple fulfillment of the IAIHG score in PBC patients [21]

2. The inclusion criteria suggested by Lohse et al., which are as follows: [3]

  • Presence of bile duct damage and hepatic lesions in the biopsy specimen of AMA-positive patients
  • Alanine aminotransferase (ALT) levels above twice the normal in an AMA-positive patient or the presence of high-titer ANA or ASMA or any titer SLA/LP autoantibodies in an AMA-positive patient.

The criteria proposed by Chazouilleres et al. (Paris criteria) [2]

3. An AIH-PBC overlap syndrome is accepted when two or three criteria of PBC as well as AIH are fulfilled. For PBC:

Alkaline phosphatase (ALP) >2 times the upper normal limit or gamma-glutamyl transferase (GGT) >5 times the upper normal limit

AMA positivity

Florid bile duct lesions.

For AIH:

ALT > 5 times the upper reference range, IgG > 2 times the upper reference range, or ASMA positivity

Portal or periportal lymphocytic inflammation and moderate to severe periportal lymphocytic piecemeal necrosis

Out of these, the criteria suggested by Lohse et al. are very subjective. For the use of IAIHG scoring system, there is a recent report by the IAIHG which suggests that IAIHG scoring system for AIH should not be used to diagnose overlap syndrome. [66]

Although there is no consensus till date on the diagnostic criteria for PBC-AIH overlap syndrome, the Paris criteria proposed by Chazouilleres et al. have been validated individually by certain groups. [67],[68] In a study done by Kuiper et al. on 134 patients of PBC-AIH overlap syndrome, the sensitivity and specificity of Paris criteria for diagnosing overlap syndrome were found to be 92% and 97%, respectively. [68]

Non-hepatic manifestations and associations

There are various reports of PBC-AIH overlap presenting with other autoimmune manifestations like concurrent Idiopathic Thrombocytopenic Purpura  ITP and systemic sclerosis, [69] antiphospholipid syndrome, [70] concomitant ITP and Hashimoto's disease, [71] autoimmune hemolytic anemia, [72] and membranous glomerulonephritis, [73] which suggest the presence of shared genetic susceptibility factors in multiple autoimmune conditions.

Treatment and prognosis

In clinical practice, it is essential to differentiate AIH-PBC overlap syndrome from the isolated pure forms of the disease, as the therapeutic approach is rather different: The standard immunosuppressive treatment of AIH (steroids with or without Azathioprine) [74] might have a negative effect on the calcium metabolism of pure PBC patients, [75] whereas isolated ursodeoxycholic acid (UDCA) treatment seems to be inadequate in controlling liver inflammation in AIH-PBC overlap syndrome. In Lohse's series, 16 out of 20 patients diagnosed with an overlap syndrome were given immunosuppressive agents for a minimum of 2 years. During follow-up, the serum aminotransferase levels improved as did the ALP levels in 12 of 16 patients, but these were additionally given UDCA. [3] Currently, a combination of UDCA and immunosuppressants seems to be the best therapeutic option for AIH-PBC overlap syndrome. [2],[3],[76] For corticosteroid-resistant patients with AIH-PBC overlap syndrome, intermediate treatment with immunosuppressants such as Cyclosporine A has been considered. [77] Liver transplantation should be considered for end-stage liver disease.

Prognosis has been predicted on the basis of AMA autoantibody status, with AMA-negative patients having more severe bile duct damage, ductopenia, ductular hyperplasia, and a higher METAVIR fibrosis score than AMA-positive overlap syndrome, indicating that AMA status affects the clinical presentation and liver disease severity of overlap syndrome. [78]

   Aih-Psc Overlap Syndrome Top

Overlap of AIH and PSC has been described in a number of reports during the last decade in both children and adults.


The etiology of AIH-PSC overlap is unknown. PSC shares genetic risk factors with AIH (HLA B8, DR3, and Drw52), and this host-related predisposition may result in similar clinical expressions or transitions between the diseases. Conversely, HLA DR4, which predisposes to AIH, protects against PSC, and its presence does not support a strong PSC component of the variant syndrome. [79],[80],[81],[82],[83] As both AIH and PSC can be associated with IBD, there is a study suggesting that the liver disease is driven by the recruitment of effector lymphocytes that were activated in the gut. [84] Twenty percent of the T cells infiltrating the liver in AIH/PSC complicating IBD are a4b7 + CCR9 + and thus of gut origin, whereas these cells are found at very low frequencies in other liver diseases, [85],[86] although this hypothesis does not explain the presence of liver disease in the absence of IBD.

Clinical presentation

The presentation of AIH-PSC overlap shows subtle differences between children and adults. Wilschanski and colleagues had described 32 children with radiological evidence of PSC, out of whom 9 were originally described as AIH. Intrahepatic biliary disease had predominated. Also, the age of AIH-PSC patients group was higher. [36] Gregorio et al., in their largest 16-year prospective study, evaluated 55 children who underwent endoscopic retrograde cholangiography (ERCP). Twenty-three (41.8%) had abnormal cholangiography, but only two had typical structuring and beading pattern as described in adults. They also observed that IBD was more common in those with overlap (12 patients, 44%) than in those with AIH alone (5 patients, 18%). [6]

The subjects affected present with stenosis and dilatation of biliary ducts during ERCP, with typical histological "chronic hepatitis like" lesions and high ANA titers in the serum. [79]

Co-existence of AIH-PSC appears to be much less frequent in adults than in children. Abdo et al. had presented a series of six adults with AIH in whom (mean 4.6 years) PSC was first demonstrated by ERCP only later. In this series, similar to children with AIH-PSC overlap, no evidence of biliary pathology was found initially. [7]

There are no particular differences between AIH-PSC overlap syndrome and PSC with regard to the clinical features or the serological parameters, except for IgG levels, which seem to be higher in overlap syndrome than in PSC alone, and for ANA and ASMA, which also have a higher prevalence in overlap syndrome. [80] AIH and PSC may be sequential in their occurrence and this has been described both in children [81] and adults. [82] Diagnostic difficulties occur mainly in children and adults with normal cholangiograms. ASC is a disorder described in children who have the clinical phenotype of AIH but with abnormal cholangiogram. IBD is typically absent, and response to corticosteroid therapy is similar to that in classical type 1 AIH. [6],[87],[88],[89],[90] Adults with AIH, cholestatic features, seronegativity for AMA, and normal cholangiograms are another diagnostic problem as they may have small duct PSC. [91],[92] High serum ALP activity or a ratio of serum ALP level to aspartate aminotransferase level (ALP: AST) that exceeds 1.5 suggests the existence of an AIH-PSC overlap, especially if biliary changes are evident on liver biopsy examination and IBD is present. [93] Recently, the use of Cytokeratin 7 stain showed that it may facilitate the identification of early intrahepatic biliary obstruction. [94]

Non-hepatic manifestations

Both AIH and PSC can be associated with IBD. [95] Association of AIH-PSC overlap syndrome with ulcerative colitis (UC) is more common than with Crohn's disease. [96]


The diagnosis of AIH-PSC overlap syndrome is based on clinical and histological criteria, together with typical ERCP findings. A scoring system for the diagnosis of AIH-PSC overlap syndrome was devised, [97],[98] but it is possibly biased by patients' age and the range of autoantibodies considered, and a call for more and better validated data was made. [98]

Magnetic resonance cholangiopancreatography MRCP has been proposed in certain studies as a preliminary non-invasive imaging modality in the detection of PSC-induced changes, especially in children. [99]


Since transaminitis is not unusual in the initial stages of PSC which could be attributed to stones or cholangitis, it is possibly prudent to start treatment with UDCA to improve cholestasis prior to introduction of any immunosuppressive therapy. This has been shown to improve the biochemical picture of cholestasis, liver histology, and even the cholangiographic features of this disease, particularly in a dose >20 mg/kg/day. [100],[101] In individuals presenting with features of AIH, it is probably optimal for immunosuppressive therapy to be the first line of treatment, particularly in patients who have florid symptoms and/or bridging necrosis on liver histology. UDCA in combination with an immunosuppressive regimen (Azathioprine ± corticosteroids) may be adequate medical treatment for most patients with AIH-PSC overlap, although data from controlled trials are lacking. Recently, the clinical benefit of UDCA has been under debate. In many single-center and multicenter trials, UDCA was found to improve disease manifestation in PSC. [102],[103],[104] But another multicenter trial with high doses of UDCA demonstrated that despite the improvement of diagnostic parameters, patients either developed varices or had to undergo liver transplantation. [105] Similarly, inconsistent results have been reported regarding the chemopreventive role of UDCA in cholangiocarcinoma and colon cancer. [106],[107],[108],[109] On the other hand, a recent study showed that patients treated with high-dose UDCA had a significantly higher risk of developing colorectal neoplasia, compared with those who received placebo. [108] For the same reasons, the American Association for the Study of Liver Diseases (AASLD) does not recommend the use of UDCA in any patient with PSC, while it is recommended by the European and German guidelines. The pediatric patients usually respond to corticosteroids, unlike patients with classical PSC, although as the biliary features progress, response to immunosuppression may be lost. The reasons for the relative treatment resistance of AIH with biliary features are not known. One possibility is that biliary epithelial cells maintain effector cell survival by providing anti-apoptotic signals through cell-surface integrin ligands such as vascular cell adhesion molecule 1 (VCAM-1) and by secreting cytokines. [110] Endoscopic therapy (ERCP) may be required for dilatation of strictures, stone removal, and other standard indications. Liver transplantation may be required earlier in a younger population than adults.


There are conflicting reports regarding the prognosis of patients with AIH-PSC overlap syndrome. In Wilschanski's study of children with overlap, 5 out of 9 (55.6%) required liver transplantation, while only 5 of 22 (22.7%) with PSC and only minor features of AIH progressed to liver transplantation. [36] Gregorio et al. also noticed in their study that four children required liver transplantation, three of whom had ASC and ductopenia on liver biopsy. [6] Hence, overlap of AIH with PSC has a poorer prognosis than AIH alone.

A systematic review of presentation and outcomes of patients with overlap syndromes at a tertiary referral center has also demonstrated that the survival of patients with PSC-AIH overlap syndrome was significantly lower than that of patients with definite AIH or PBC-AIH overlap syndrome. [111]

   PBC-PSC: Overlap Syndrome Or Coexistence? Top

Different from AIH-PBC and AIH-PSC overlap syndromes, evidence for a PBC-PSC overlap syndrome is limited at best and is based only on single case reports. [39],[40],[41] In a recently described case, a 64-year-old woman with PBC of 17-year duration revealed typical benign strictures and dilatation of common bile duct with typical beading suggestive of PSC on ERCP done for worsening cholestatic features. [41]

Whether sclerosing bile duct injury can be regarded as a primary event in late stage hepatopathies of other cause remains elusive.

   Conclusion Top

Overlap syndrome in hepatology is emerging as a diagnostic and therapeutic challenge. This in turn emphasizes our current ignorance regarding the immunopathogenesis leading to these diseases. The diagnostic strategies currently available are summarized in [Table 1]. In future, certain steps should be taken to exactly delineate the clinical issue and find probable solutions:
Table 1: Diagnostic strategies for overlap syndromes

Click here to view

  1. Collect a large database of autoimmune liver diseases, keeping in mind the sample size, biases in the methods used and selection of patients by uniform application of a systemic algorithm
  2. Immunogenetic studies to illuminate the pathogenesis of disease
  3. Develop a comprehensive scoring system and reevaluate the available ones in a more rigorous manner
  4. Large randomized studies to evaluate the impact of drug therapy on the natural history of overlap syndrome
  5. Define biomarkers for diagnosis, prognosis, as well as for susceptibility testing.

With the ultimate goal of predicting and possibly preventing autoimmune liver diseases, it will be important to thoroughly investigate individual areas of pure as well as overlapping forms of the disorder. This is needed as the chances of progression to liver transplant remains high in cases like AIH-PSC overlap and early recognition may alter the course of the illness.

   References Top

1.Washington MK. Autoimmune liver disease: Overlap and overlier. Mod Pathol 2007;20 Suppl 1:S15-30.  Back to cited text no. 1
2.Chazouilleres O, Wendum D, Serfaty L, Montembault S, Rosmorduc O, Poupon R. Primary biliary cirrhosis - Autoimmune hepatitis overlap syndrome: Clinical features and response to therapy. Hepatology 1998;28:296-301.  Back to cited text no. 2
3.Lohse AW, zum Bushenfeld KH, Franz B, Kanzler S, Gerken G, Dienes HP. Characterization of overlap syndrome of Primary biliary cirrhosis and autoimmune hepatitis: Evidence for it being a hepatic form of primary biliary cirrhosis in genetically susceptible individuals. Hepatology 1999;29:1078-84.  Back to cited text no. 3
4.Colombato LA, Alvarez F, Cote J, Huet PM. Autoimmune cholangiopathy the result of consecutive primary biliary cirrhosis and autoimmune hepatitis? Gastroenterology 1994;107:1839-43.  Back to cited text no. 4
5.Twaddell WS, Lefkowitch J, Berk PD. Evolution from primary biliary cirrhosis to primary biliary cirrhosis/autoimmune hepatitis overlap syndrome. Semin Liver Dis 2008;28:128-34.  Back to cited text no. 5
6.Gregorio GV, Portmann B, Karani J, Harrison P, Donaldson PT, Vergani D, et al. Autoimmune hepatitis/sclerosing cholangitis overlap syndrome in childhood: A 16-year prospective study. Hepatology 2001:33:544-53.  Back to cited text no. 6
7.Abdo AA, Bain VG, Kichian K, Lee SS. Evolution of autoimmune hepatitis to primary sclerosing cholangitis: A sequential syndrome. Hepatology 2002;36:1393-9.  Back to cited text no. 7
8.Beuers U, Rust C. Overlap syndromes. Semin Liver Dis 2005;25:311-20.  Back to cited text no. 8
9.Czaja AJ. The variant forms of autoimmune hepatitis. Ann Intern Med 1996;125:588-98.  Back to cited text no. 9
10.Mattiuzzo M, Botsios C, Biscaro R. Sequential manifestation of autoimmune diseases: An unusual case. Eur J Gastroenterol Hepatol 2006;18:777-80.  Back to cited text no. 10
11.Patel N, Amrapurkar D, Amrapurkar A. Primary biliary cirrhosis and autoimmune hepatitis switch over: Report of two cases. Trop Gastroenterol 2005;26:136-8.  Back to cited text no. 11
12.Beuers U. Hepatic overlap syndromes. J Hepatol 2005;42:S93-99.  Back to cited text no. 12
13.Nezu S, Tanaka A, Yasui H, Imamura M, Nakajima H, Ishida H, et al. Presence of antimitochondrial autoantibodies in patients with autoimmune hepatitis. J Gastroenterol Hepatol 2006;21:1448-54.  Back to cited text no. 13
14.O'Brien C, Joshi S, Feld JJ, Guindi M, Dienes HP, Heathcote EJ. Long-term follow-up of antimitochondrial antibody positive autoimmune hepatitis. Hepatology 2008;48:550-6.  Back to cited text no. 14
15.Sato Y, Harada K, Sudo Y, Watanabe K, Nakahama T, Morimoto H, et al. Autoimmune hepatitis associated with bile duct injury resembling chronic non suppurative destructive cholangitis. Pathol Int 2002;52:478-82.  Back to cited text no. 15
16.Mishima S, Omagari K, Ohba K, Kadokawa Y, Masuda J, Mishima R, et al. Clinical implications of antimitochondrial antibodies in type I autoimmune hepatitis: A longitudinal study. Hepatogastroenterology 2008;55:221-7.  Back to cited text no. 16
17.Poupon R. Autoimmune overlapping syndromes. Clin Liver Dis 2003;7:865-78.  Back to cited text no. 17
18.Czaja AJ, Carpenter HA, Santrach PJ, Moore SB. Autoimmune cholangitis within the spectrum of autoimmune liver disease. Hepatology 2000;31:1231-8.  Back to cited text no. 18
19.Ben-Ari Z, Czaja AJ. Autoimmune hepatitis and its variant syndromes. Gut 2001;49:589-94.  Back to cited text no. 19
20.Guebel AP, Baggenstoss AH, Summerskill WH. Response to treatment can differentiate chronic active liver disease with cholangitic features from primary biliary cirrhosis. Gastroenterology 1976;71:444-49.  Back to cited text no. 20
21.Muratori L, Cassini F, Pappas G, Guidi M, Mele L, Lorenza V, et al. The hepatic/cholestatic "overlap" syndrome: An Italian experience. Autoimmunity 2002;35:565-8.  Back to cited text no. 21
22.Gheorghe L, Iacob S, Gheorghe C, Iacob R, Siminov I, Vadan R, et al. Frequency and predictive factors for overlap syndrome between autoimmune hepatitis and primary cholestatic liver disease. Eur J Gastroenterol Hepatol 2004;16:585-92.  Back to cited text no. 22
23.Heurgue A, Vitry F, Diebold MD, Yaziji N, Bernard-Chabert B, Pennaforte JL, et al. Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: A retrospective study of 115 cases of autoimmune liver disease. Gastroenterol Clin Biol 2007;31:17-25.  Back to cited text no. 23
24.Gunsar F, Akarca US, Ersoz G, Karasu Z, Yuce G, Batur Y. Clinical and biochemical features and therapy responses in primary biliary cirrhosis and primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Hepatogastroenterology 2002;49:1195-200.  Back to cited text no. 24
25.Talwalkar JA, Keach JC, Angulo P, Lindor KD. Overlap of autoimmune hepatitis and primary biliary cirrhosis: An evaluation of modified scoring system. Am J Gastroenterol 2002;97:1191-7.  Back to cited text no. 25
26.Silveira MG, Talwalkar JA, Angulo P, Lindor KD. Overlap of autoimmune hepatitis and primary biliary cirrhosis: Long term outcomes. Am J Gastroenterol 2007;102:1244-50.  Back to cited text no. 26
27.Joshi S, Cauch-Dudek K, Wanless IR, Lindor KD, Jorgensen R, Batts K, et al. Primary biliary cirrhosis with additional features of autoimmune hepatitis: Response to therapy with ursodeoxycholic acid. Hepatology 2002;35:409-13.  Back to cited text no. 27
28.Suzuki Y, Arase Y, Ikeda K, Saitoh S, Tsubota A, Suzuki F, et al. Clinical and pathological characteristics of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome. J Gastroenterol Hepatol 2004;19:699-706.  Back to cited text no. 28
29.Wagle SD, Jagtap SP, Wadia F. Primary biliary cirrhosis and autoimmune hepatitis overlap syndrome. Indian J Gastroenterol 2004;23:70-1.  Back to cited text no. 29
30.Wu CH, Wang QH, Tian GS, Xu XY, Yu YY, Wang GQ. Clinical features of the overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis: Retrospective study. Chin Med J (Engl) 2006;119:238-41.  Back to cited text no. 30
31.Alvarez F, Berg PA, Bianchi FB, Bianchi L, Burroughs AK, Cancado EL, et al. International Autoimmune Hepatitis Group report: Review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929-38.  Back to cited text no. 31
32.Czaja AJ. Frequency and nature of the variant syndromes of autoimmune liver diseases. Hepatology 1998;28:360-5.  Back to cited text no. 32
33.Boberg KM, Fausa O, Haaland T, Holter E, Mellbye OJ, Spurkland A, et al. Features of autoimmune hepatitis in primary sclerosing cholangitis: An evaluation of 114 primary sclerosing cholangitis patients according to a scoring system for the diagnosis of autoimmune hepatitis. Hepatology 1996;23:1369-76.  Back to cited text no. 33
34.van Buuren HR, van Hoogstraten HJ, Terkivatan T, Schalm SW, Vleggaar FP. High prevalence of autoimmune hepatitis among patients with primary sclerosing cholangitis. J Hepatol 2000;33:543-8.  Back to cited text no. 34
35.Kaya M, Angulo P, Lindor KD. Overlap of autoimmune hepatitis and primary sclerosing cholangitis: An evaluation of a modified scoring system. J Hepatol 2000;33;537-42.  Back to cited text no. 35
36.Wilschanski M, Chait P, Wade JA, Davis L, Corey M, St Louis P, et al. Primary sclerosing cholangitis in 32 children: Clinical, laboratory and radiographic features with survival analysis. Hepatology 1995;22:1415-22.  Back to cited text no. 36
37.Perdigoto R, Carpenter HA, Czaja AJ. Frequency and significance of chronic ulcerative colitis in severe corticosteroid treated autoimmune hepatitis. J Hepatol 1992;14:325-31.  Back to cited text no. 37
38.Abdalian R, Dhar P, Jhaveri K, Haider M, Guindi M, Heathcote EJ. Prevalence of sclerosing cholangitis in adults with autoimmune hepatitis: Evaluating the role of routine magnetic resonance imaging. Hepatology 2008;47:949-57.  Back to cited text no. 38
39.Rubel LR, Seeff LB, Patel V. Primary biliary cirrhosis-primary sclerosing cholangitis overlap syndrome. Arch Pathol Lab Med 1984;108:360-1.  Back to cited text no. 39
40.Burak KW, Urbanski SJ, Swain MG. A case of coexisting Primary biliary cirrhosis and primary sclerosing cholangitis: A new overlap of autoimmune liver diseases. Dig Dis Sci 2001;46:2043-47.  Back to cited text no. 40
41.Jeevgan A. Overlap of Primary biliary cirrhosis and primary sclerosing cholangitis - a rare coincidence or a new syndrome. Int J Gen Med 2010;3:143-6.  Back to cited text no. 41
42.Li CP, Tong MJ, Hwang SJ, Luo JC, Co RL, Tsay SH, et al. Autoimmune cholangitis with features of autoimmune hepatitis: Successful treatment with immunosuppressive agents and ursodeoxycholic acid. J Gastroenterol Hepatol 2000;15:95-8.  Back to cited text no. 42
43.Yamamoto K, Terada R, Okamoto R, Hiasa Y, Abe M, Onji M, et al. A scoring system for primary biliary cirrhosis and its application for variant forms of autoimmune liver disease. J Gastroenterol 2003;38:52-9.  Back to cited text no. 43
44.Zepeda-Gomez S, Montano Loza A, Zapata Colindres JC, Paz F, Olivera-Martinez M, Lopez-Reyes A, et al. HLA -DR allele frequencies in Mexican Mestizos with autoimmune liver diseases including overlap syndromes. Immunol Invest 2009;38:276-83.  Back to cited text no. 44
45.Honda M, Kawai H, Shirota Y, Yamashita T, Takamura T, Kaneko S. cDNA microarray analysis of autoimmune hepatitis, primary biliary cirrhosis and consecutive disease manifestation. J Autoimmun 2005;25:133-40.  Back to cited text no. 45
46.Coss Adame E, Granados J, Uribe M, Torre A. Does HLA-DR7 differentiate the overlap syndrome of autoimmune hepatitis-primary biliary cirrhosis (AIH-PBC) from those with autoimmune hepatitis type 1?. Ann Hepatol 2011;10:28-32.  Back to cited text no. 46
47.Weyman RL, Voigt M. Consecutive occurrence of primary biliary cirrhosis and autoimmune hepatitis: A case report and review of literature. Am J Gastroenterol 2001;96:585-7.  Back to cited text no. 47
48.Lindgren S, Glaumann H, Almer S, Bergquist A, Bjornsson E, Broome U, et al. Transition between variant forms of primary biliary cirrhosis during long term follow-up. Eur J Intern Med 2009;20:398-402.  Back to cited text no. 48
49.Gossard AA, Lindor KD. Development of autoimmune hepatitis in primary biliary cirrhosis. Liver Int 2007;27:1086-90.  Back to cited text no. 49
50.Horsmans Y, Piret A, Brenard R, Rahier J, Geubel AP. Autoimmune chronic active hepatitis responsive to immunosuppressive therapy evolving into a typical primary biliary cirrhosis syndrome: A case report. J Hepatol 1994;21:194-8.  Back to cited text no. 50
51.Van Leeuwen DJ, Sood G, Ferrante D, Lazenby AJ, Sellers MJ. A 38-year -old African American woman with an unusually rapid progression of "Primary Biliary Cirrhosis": A missed opportunity! Semin Liver Dis 2002;22:395-406.  Back to cited text no. 51
52.Angulo P, El-Amin O, Carpenter HA, Lindor KD. Development of autoimmune hepatitis in the setting of long standing primary biliary cirrhosis. Am J Gastroenterol 2001;96:3021-7.  Back to cited text no. 52
53.Jones DE, James OF, Portmann B, Burt AD, Williams R, Hudson M. Development of autoimmune hepatitis following liver transplantation for primary biliary cirrhosis. Hepatology 1999;30:53-7.  Back to cited text no. 53
54.Rodriguez-Diaz Y, Reyes-Rodriguez R, Dorta-Francisco MC, Aguilera I, Perera-Molinero A, Moneva-Arce E, et al. De novo autoimmune hepatitis following liver transplantation for primary biliary cirrhosis. Transplant Proc 2006;38:1467-70.  Back to cited text no. 54
55.Yoshizawa K, Shirakawa H, Ichijo T, Umemura T, Tanaka E, Kiyosawa K, et al. De novo autoimmune hepatitis following living-donor liver transplantation for primary biliary cirrhosis. Clin Transplant 2008;22:385-90.  Back to cited text no. 55
56.Hytiroglou P, Gutierrez JA, Freni M, Odin JA, Stanca CM, Merati S, et al. Recurrence of primary biliary cirrhosis and development of autoimmune hepatitis after liver transplant: A blind histologic study. Hepatol Res 2009;39:577-84.  Back to cited text no. 56
57.Saxena R, Kim Schluger L, Klion F, Scheiner P, Thung S, Bodenheimer Jr HC. Autoimmune hepatitis in the liver allografts of patients transplanted for PBC and overlap syndrome. Gastroenterology 1998;114:A1335.  Back to cited text no. 57
58.Kayacetin E, Koklu S, Temucin T. Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis with unusual initial presentation as fulminant hepatic failure. Dig Liver Dis 2004;36:419-22.  Back to cited text no. 58
59.Lee H, Stapp RT, Ormsby AH, Shah W. The Usefulness of IgG and IgM Immunostaining of Periportal Inflammatory Cells (Plasma Cells and Lymphocytes) for the Distinction of Autoimmune Hepatitis and Primary Biliary Cirrhosis and Their Staining Pattern in Autoimmune Hepatitis-Primary Biliary Cirrhosis Overlap Syndrome. Am J Clin Pathol 2010;133:430-7.  Back to cited text no. 59
60.Invernizzi P, Podda M, Battezzati PM, Crosignani A, Zuin M, Hitchman E, et al. Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis. J Hepatol 2001;34:366-72.  Back to cited text no. 60
61.Muratori P, Muratori L, Ferrari R, Cassani F, Bianchi G, Lenzi M, et al. Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis. Am J Gastroenterol 2003;98:431-7.  Back to cited text no. 61
62.Muratori P, Granito A, Pappas G, Pendino GM, Quarneti C, Cicola R, et al. The serological profile of the autoimmune hepatitis/primary biliary cirrhosis overlap syndrome. Am J Gastroenterol 2009;104:1420-5.  Back to cited text no. 62
63.Kanzler S, Bozkurt S, Herkel J, Galle PR, Dienes HP, Lohse AW. Presence of SLA/LP autoantibodies in patients with primary biliary cirrhosis as a marker for secondary autoimmune hepatitis (overlap syndrome). Dtsch Med Wochenschr 2001;126:450-6.  Back to cited text no. 63
64.Czaja AJ, Shums Z, Norman GL. Frequency and significance of antibodies to soluble liver antigen/liver pancreas in variant autoimmune hepatitis. Autoimmunity 2002;35;475-83.  Back to cited text no. 64
65.Csepregi A, Obermayer-Straub P, Kneip S, Kayser A, Loges S, Schmidt E, et al. Characterization of a lipoyl domain-independent B-cell autoepitope on the human branched chain acyltransferase in primary biliary cirrhosis and overlap syndrome with autoimmune hepatitis. Clin Dev Immunol 2003;10:173-81.  Back to cited text no. 65
66.Boberg KM, Chapman RW, Hirschfield GM, Lohse AW, Manns MP, Schrumpf E; International Autoimmune Hepatitis Group. Overlap Syndromes: The International Autoimmune Hepatitis Group (IAIHG) Position Statement on a Controversial Issue. J Hepatol 2011;54:374-85.  Back to cited text no. 66
67.Kuiper EM, Zondervan PE, van Buure HR. Chazouilleres criteria are superior to the revised and simplified autoimmune hepatitis scores for diagnosing the overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis. J Hepatol 2009;50:S246-7.  Back to cited text no. 67
68.Kuiper EM, Zondervan PE, van Buure HR. Paris Criteria Are Effective in Diagnosis of Primary Biliary Cirrhosis and Autoimmune Hepatitis Overlap Syndrome. Clin Gastroenterol Hepatol 2010;8:530-4.  Back to cited text no. 68
69.Toyoda M, Yokomori H, Kaneko F, Yoshida H, Hoshi K, Takeuchi H, et al. Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome concomitant with systemic sclerosis, immune thrombocytopenic purpura. Intern Med 2009;48:2019-23.  Back to cited text no. 69
70.Targoñska-Stepniak B, Majdan M, Suszek D, Laskowska K. Overlap syndrome autoimmune hepatitis and primary biliary cirrhosis associated with antiphospholipid syndrome. Pol Merkur Lekarski 2006;21:480-3.  Back to cited text no. 70
71.Arakawa Y, Amaki S, Miyakawa H, Sakai T, Gotou I, Tanaka N, et al. PBC-AIH overlap syndrome with concomitant ITP and Hashimoto's disease with positivity for anti-centromere antibody. J Gastroenterol 2004;39:490-5.  Back to cited text no. 71
72.Gentile M, Verta M, Vigna E, Lucia E, Mazzone C, Perugini D, et al. Autoimmune hemolityc anemia concomitant with sequential autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and Hashimoto's thyroiditis: A new entity of autoimmune polyendocrine syndrome. J Endocrinol Invest 2009;32:287-8.  Back to cited text no. 72
73.Efe C, Ozaslan E, Purnak T, Ozturk R. Membranous glomerulonephritis associated with autoimmune hepatitis and primary biliary cirrhosis overlap syndrome: A very rare condition. Eur J Gastroenterol Hepatol 2010;22:1149-50.  Back to cited text no. 73
74.Czaja AJ. Treatment of autoimmune hepatitis. Semin Liver Dis 2002;22:365-78.  Back to cited text no. 74
75.Levy C, Lindor KD. Management of osteoporosis, fat soluble vitamin deficiencies and hyperlipidemia in primary biliary cirrhosis. Clin Liver Dis 2003;7:901-10.  Back to cited text no. 75
76.Chazouilleres O, Wendum D, Serfaty L, Rosmorduc O, Poupon R. Long term outcome and response to therapy of primary biliary cirrhosis - autoimmune hepatitis overlap syndrome. J Hepatol 2006;44:400-6.  Back to cited text no. 76
77.Duclos-Vallee JC, Hadengue A, Ganne-Carrie N, Robin E, Degott C, Erlinger S. Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Corticoresistance and effective treatment by Cyclosporine A. Dig Dis Sci 1995;40:1069-73.  Back to cited text no. 77
78.Alric L, Thebault S, Selves J, Peron JM, Mejdoubi S, Fortenfant F, et al. Characterization of overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis according to antimitochondrial antibodies status Gastroentérol Clin Biol 2007;31:11-6.  Back to cited text no. 78
79.Czaja AJ, Santrach PJ, Breanndan Moore S. Shared genetic risk factors in autoimmune liver disease. Dig Dis Sci 2001;46:140-7.  Back to cited text no. 79
80.Chapman RW, Varghese Z, Gaul R, Patel G, Kokinon N, Sherlock S. Association of primary sclerosing cholangitis with HLA-B8. Gut 1983;24:38-41.  Back to cited text no. 80
81.Prochazka EJ, Terasaki PI, Park MS, Goldstein LI, Busuttil RW. Association of primary sclerosing cholangitis with HLA-DRw52a. N Engl J Med 1990;322:1842-4.  Back to cited text no. 81
82.Donaldson PT, Farrant JM, Wilkinson ML, Hayllar K, Portmann BC, Williams R. Dual association of HLA DR2 and DR3 with primary sclerosing cholangitis. Hepatology 1991;13:129-33.  Back to cited text no. 82
83.Farrant JM, Doherty DG, Donaldson PT, Vaughan RW, Hayllar KM, Welsh KI, et al. Amino acid substitutions at position 38 of the DRâ polypeptide confer susceptibility to and protection from primary sclerosing cholangitis. Hepatology 1992;16:390-5.  Back to cited text no. 83
84.Grant AJ, Lalor PF, Salmi M, Jalkanen S, Adams DH. Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease. Lancet 2002;359:150-7.  Back to cited text no. 84
85.Agace WW. T-cell recruitment to the intestinal mucosa. Trends Immunol 2008;29:514-22.  Back to cited text no. 85
86.Eksteen B, Grant AJ, Miles A, Curbishley SM, Lalor PF, Hubscher SG, et al. Hepatic endothelial CCL25 mediates the recruitment of CCR9? gut-homing lymphocytes to the liver in primary sclerosing cholangitis. J Exp Med 2004;200:1511-7.  Back to cited text no. 86
87.Gregorio GV, Portmann B, Reid F, Donaldson PT, Doherty DG, McCartney M, et al. Autoimmune hepatitis in childhood: A 20 year survey. Hepatology 1997;25:541-7.  Back to cited text no. 87
88.Mieli-Vergani G, Vergani D. Immunological liver diseases in children. Semin Liver Dis 1998;18:271-9.  Back to cited text no. 88
89.Roberts EA. Primary sclerosing cholangitis in children. J Gastroenterol Hepatol 1999;14:588-93.  Back to cited text no. 89
90.Mieli-Vergani G. Autoimmune sclerosing cholangitis: A distinct clinical entity? J Hepatol 2000;32:7-8.  Back to cited text no. 90
91.Perdigoto R, Carpenter HA, Czaja AJ. Frequency and significance of chronic ulcerative colitis in severe corticosteroid-treated autoimmune hepatitis. J Hepatol 1992;14:325-31.  Back to cited text no. 91
92.Wee A, Ludwig J. Pericholangitis in chronic ulcerative colitis: Primary sclerosing cholangitis of the small bile ducts? Ann Intern Med 1985;102:581-7.  Back to cited text no. 92
93.McNair AN, Moloney M, Portmann BC, Williams R, McFarlane IG. Autoimmune hepatitis overlapping primary sclerosing cholangitis in five cases. Am J Gastroenterol 1998;93:777-84.  Back to cited text no. 93
94.Goldstein NS, Soman A, Gordon SC. Portal tract eosinophils and hepatocyte cytokeratin 7 immunoreactivity helps distinguish early stage, mildly active primary biliary cirrhosis and automimune hepatitis. Am J Clin Pathol 2001;116:846-53.  Back to cited text no. 94
95.Saich R, Chapman R. Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease. World J Gastroenterol 2008;14:331-7.  Back to cited text no. 95
96.Malik TA, Gutierrez AM, McGuire B, Zarzour JG, Mukhtar F, Bloomer J. Autoimmune Hepatitis-Primary Sclerosing Cholangitis Overlap Syndrome Complicated by Crohn's Disease. Digestion 2010;82:24-6.  Back to cited text no. 96
97.Kaya M, Angulo P, Lindor KD. Overlap of autoimmune hepatitis and primary sclerosing cholangitis: An evaluation of a modified scoring system. J Hepatol 2000;33:537-42.  Back to cited text no. 97
98.Chazouilleres O. Diagnosis of primary sclerosing cholangitis- autoimmune hepatitis overlap syndrome: To score or not to score? J Hepatol 2000;33:661-3.  Back to cited text no. 98
99.Saltik-Temizel NI, Koçak N, Ergen FB, Akhan O. Autoimmune hepatitis/sclerosing cholangitis overlap syndrome with inflammatory bowel disease in a boy: Role of MR cholangiopancreatography in the diagnosis. Eur J Radiol 2004;50:45-7.  Back to cited text no. 99
100.Mitchell SA, Bansi DS, Hunt N, Von Bergmann K, Fleming KA, Chapman RW. A preliminary trial of high dose ursodeoxycholic acid as a therapy in primary sclerosing cholangitis. Gastroenterology 2001;121:900-7.  Back to cited text no. 100
101.Harnois DM, Angulo P, Jorgensen RA, Larusso NF, Lindor KD. High dose ursodeoxycholic acid as atherapy for patients with primary sclerosing cholangitis. Am J Gastroenterol 2001;96:1558-62.  Back to cited text no. 101
102.Beuers U, Spengler U, Kruis W, Aydemir U, Wiebecke B, Heldwein W, et al. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial. Hepatology 1992;16:707-14.  Back to cited text no. 102
103.Lindor KD. Ursodiol for primary sclerosing cholangitis Mayo Primary Sclerosing Cholangitis-Ursodeoxycholic Acid Study Group. N Engl J Med 1997;336:691-5.  Back to cited text no. 103
104.Stiehl A, Walker S, Stiehl L, Rudolph G, Hofmann WJ, Theilmann L. Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis: A 3-year pilot study with a placebo-controlled study period. J Hepatol 1994;20:57-64.  Back to cited text no. 104
105.Lindor KD, Kowdley KV, Luketic VA, Harrison ME, McCashland T, Befeler AS, et al. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology 2009;50:808-14.  Back to cited text no. 105
106.Tung BY, Emond MJ, Haggitt RC, Bronner MP, Kimmey MB, Kowdley KV, et al. Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. Ann Intern Med 2001;134:89-95.  Back to cited text no. 106
107.Pardi DS, Loftus EV Jr, Kremers WK, Keach J, Lindor KD. Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis. Gastroenterology 2003;124:889-93.  Back to cited text no. 107
108.Eaton JE, Silveira MG, Pardi DS, Sinakos E, Kowdley KV, Luketic VA, et al. High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. Am J Gastroenterol 2011;106:1638-45.  Back to cited text no. 108
109.Lindstrom L, Boberg KM, Wikman O, Friis-Liby I, Hultcrantz R, Prytz H, et al. High dose ursodeoxycholic acid in primary sclerosing cholangitis does not prevent colorectal neoplasia. Aliment Pharmacol Ther 2012;35:451-7.  Back to cited text no. 109
110.Oo YH, Hubscher SG, Adams DH. Autoimmune hepatitis: New paradigms in the pathogenesis, diagnosis, and management. Hepatol Int 2010;4:475-93.  Back to cited text no. 110
111.Al-Chalabi T, Portmann BC, Bernal W, Mcfarlene IG, Heneghan MA. Autoimmune hepatitis overlap syndromes: An evaluation of treatment response, long-term outcome and survival. Aliment Pharmacol Ther 2008;28:209-20.  Back to cited text no. 111

Correspondence Address:
Sharad Malhotra
Consultant, Medical Gastroenterology, Batra Hospital and Medical Research Centre, New Delhi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-3767.145316

Rights and Permissions


  [Table 1]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  

    Epidemiology of ...
    Aih-Pbc Overlap ...
    Aih-Psc Overlap ...
    PBC-PSC: Overlap...
    Article Tables

 Article Access Statistics
    PDF Downloaded576    
    Comments [Add]    

Recommend this journal