| ORIGINAL ARTICLE |
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| Year : 2015 | Volume
: 21
| Issue : 3 | Page : 139-145 |
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The relationship of circulating fetuin-a with liver histology and biomarkers of systemic inflammation in nondiabetic subjects with nonalcoholic fatty liver disease
Gurkan Celebi1, Halil Genc1, Hasan Gurel1, Erdim Sertoglu2, Muammer Kara3, Serkan Tapan4, Cengizhan Acikel5, Yildirim Karslioglu6, Cemal Nuri Ercin1, Teoman Dogru1
1 Department of Gastroenterology, Gulhane School of Medicine, Ankara, Turkey
2 Department of Medical Biochemistry, Beytepe Military Hospital, Ankara, Turkey
3 Department of Gastroenterology, Gulhane School of Medicine, Istanbul, Turkey
4 Department of Medical Biochemistry, Gulhane School of Medicine, Ankara, Turkey
5 Department of Epidemiology, Gulhane School of Medicine, Ankara, Turkey
6 Department of Pathology, Gulhane School of Medicine, Ankara, Turkey
Correspondence Address:
Gurkan Celebi
Department of Gastroenterology, Gulhane School of Medicine, Tevfik Saglam Street, 06018, Etlik, Ankara
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1319-3767.157556
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Background/Aims: Fetuin-A, a glycoprotein with anti-inflammatory properties, plays an important role in counter-regulating inflammatory responses. It has also been associated with insulin resistance and metabolic syndrome. We aimed to investigate circulating concentrations of fetuin-A and its possible association with hepatic and systemic inflammation in nondiabetic subjects with nonalcoholic fatty liver disease (NAFLD). Patients and Methods: We included 105 nondiabetic male subjects with NAFLD [nonalcoholic steatohepatitis (NASH, n = 86) and simple steatosis (SS, n = 19)]. Plasma levels of fetuin-A and markers of inflammation [high-sensitive C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and adiponectin] were measured by enzyme-linked immunosorbent assay method. Insulin sensitivity was determined by homeostasis model assessment of insulin resistance (HOMA-IR) index. Results: Fetuin-A was negatively correlated with age (r = −0.27, P = 0.006), however there was no association between fetuin-A and body mass index, waist circumference (WC), glucose, insulin, HOMA-IR, lipid parameters, and inflammatory markers. In addition, no significant association was observed between fetuin-A and histological findings including liver fibrosis. Conclusion: This study demonstrated that plasma fetuin-A levels are not correlated with the hepatic histology and systemic markers of inflammation in nondiabetic subjects with NAFLD. Our data also suggested that age is significantly associated with fetuin-A in this clinically relevant condition. |
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