Saudi Journal of Gastroenterology
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Year : 2015  |  Volume : 21  |  Issue : 6  |  Page : 423-426

Gastric calcifying fibrous tumor: A case of suspected immunoglobulin G4-related gastric disease

Department of Gastroenterology, Peking University Third Hospital, Beijing, China

Correspondence Address:
Dr. Shigang Ding
No. 49 Road Huayuan North, Haidian District, Beijing - 100191, PR
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-3767.170950

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Gastrointestinal lesions resulting from immunoglobulin G4-related disease are classified into two types: One is a gastrointestinal lesion showing marked thickening of the wall, and the other is an IgG4-related pseudotumor. We report the case of a woman with gastric calcifying fibrous tumor undergoing endoscopic resection that contained 62 IgG4+ plasma cells per high-power field and an IgG4-to-IgG ratio of 41% in lesional plasma cells, which shared clinical and histopathological features associated with gastric IgG4-related pseudotumor. So, we postulate that calcifying fibrous tumor as part of the spectrum of IgG4-related disease might be the unifying concept with IgG4-related pseudotumor. Meanwhile, the patient had coexistent autoimmune diseases, including autoimmune atrophic gastritis, Hashimoto's thyroiditis, and possible primary biliary cirrhosis. The clinical follow-up evaluation was uneventful.

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