Saudi Journal of Gastroenterology
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Year : 2016  |  Volume : 22  |  Issue : 2  |  Page : 106-108

Impact of pediatric inflammatory bowel disease on linear growth: Data from a national cohort study in Saudi Arabia

1 Department of Pediatrics, Head, Pediatric Inflammatory Bowel Disease Research Group, Member of Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia
2 Al Mofarreh PolyClinic, Department of Gastroenterology, Riyadh, Saudi Arabia
3 Department of Pediatrics, Faculty of Medicine and Inflammatory Bowel Disease Research Group, King Abdul Aziz University, Riyadh, Saudi Arabia
4 The Children's Hospital, Division of Gastroenterology, Hepatology, King Fahad Medical City, Riyadh, Saudi Arabia
5 Department of Pediatrics, Section of gastroenterology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Correspondence Address:
Mohammad I El Mouzan
Department of Pediatrics, Gastroenterology Division, PO Box 2925, Riyadh - 11461
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-3767.178524

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Background/Aim: Linear growth impairment (LGI) is one of the most important features peculiar to children with inflammatory bowel disease (IBD). The aim of this report is to define the impact of IBD on the linear growth of children in the Kingdom of Saudi Arabia (KSA). Setting and Design: Multicenter retrospective study. Patients and Methods: Data from a cohort of newly- diagnosed children with IBD from 2003 to 2012 were analyzed retrospectively. The diagnosis of IBD was confirmed in accordance with the published criteria. Length/height for age was measured at diagnosis. The World Health Organization (WHO) reference was used and LGI was defined by length/height for age <-2 standard deviation. Chi-square test was used to test the significance of estimates and a P < 0.05 was considered significant. Results: There were 374 children from 0.33 to 16 years of age, including 119 ulcerative colitis (UC) (32%), and 255 Crohn's disease (CD) (68%) patients. The prevalence of LGI was 26%, 28%, and 21% in IBD, CD, and UC, respectively. In children below 10 years, LGI was significantly more common in CD (P = 0.010), while in UC children, it was more common in older children (P = 0.011). Conclusion: This study demonstrates a prevalence of LGI consistent with that reported in the literature, but higher in CD children with early onset (<10 years) and in older children with UC, underscoring the importance of monitoring growth in children with IBD in the Saudi population. Prospective studies are needed to define the impact of IBD on growth velocity, puberty, and final adult stature.

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