Saudi Journal of Gastroenterology
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Year : 2021  |  Volume : 27  |  Issue : 6  |  Page : 319-330

Nonalcoholic fatty liver disease: The role of quercetin and its therapeutic implications

1 Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
2 Department of Gastroenterology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
3 Center of Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece
4 Department of Pharmacy, Laboratory of Biopharmaceutics-Pharmacokinetics, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece
5 Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

Correspondence Address:
Dr. Michail Vailas
Department of Surgery, Laikon General Hospital, 17 Agiou Thoma, Athens 11527
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjg.sjg_249_21

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Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting almost one-third of the general population and 75% of obese patients with type 2 diabetes. The aim of this article is to review the current evidence concerning the role of quercetin, a natural compound and flavonoid, and its possible therapeutic effects on this modern-day disease. Despite the fact that the exact pathophysiological mechanisms through which quercetin has a hepatoprotective effect on NAFLD are still not fully elucidated, this review clearly demonstrates that this flavonoid has potent antioxidative stress action and inhibitory effects on hepatocyte apoptosis, inflammation, and generation of reactive oxygen species, factors which are linked to the development of the disease. NAFLD is closely associated with increased dietary fat consumption, especially in Western countries. The hepatoprotective effect of quercetin against NAFLD merits serious consideration and further validation by future studies.

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