Saudi Journal of Gastroenterology
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ORIGINAL ARTICLE
Year : 2022  |  Volume : 28  |  Issue : 6  |  Page : 417-425

Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis


Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

Correspondence Address:
Dr. Song He
Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing - 400010
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjg.sjg_441_21

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Background: Acute pancreatitis (AP) is a common digestive system disease, and its incidence is increasing year by year. Although some clinical studies have indicated that cholecystectomy can reduce the risk of recurrent pancreatitis after acute biliary pancreatitis (ABP), it is not clear whether cholecystectomy would affect the severity of subsequent AP. Methods: In this study, we combined computed tomography scoring index (CTSI), bedside index for severity in AP (BISAP), and clinical manifestations grading of AP with propensity score matching (PSM), after correction for baseline confounding factors, to respectively explore the influence of cholecystectomy on the severity of subsequent pancreatitis in 527 AP patients. Results: The results showed that ABP (231/527) is more common in female patients and elderly patients (P < 0.001). Age, amylase, creatinine, blood urea nitrogen, and aspartate aminotransferase levels of patients with ABP at admission were higher than those of non-biliary pancreatitis (296/527), and the levels of albumin, hematocrit, and blood glucose were lower (P < 0.050). Further, compared with the unresected group (458/527), patients after cholecystectomy (69/527) had less white blood cells and higher level of albumin (P < 0.050). Patients had lower clinical manifestation grade (P = 0.019) and CTSI grade (P < 0.008) after cholecystectomy. After PSM correction, there was no difference in biochemical parameters between the cholecystectomy group and the non-cholecystectomy group, but differences in clinical manifestation grade (P = 0.039) and CTSI grade (P = 0.013) remained. We also found that cholecystectomy reduced the frequency of biliary pancreatitis (30.4% vs. 45.9%, P < 0.050). Finally, we found that cholecystectomy could reduce the severity of subsequent idiopathic AP. Conclusion: Cholecystectomy could reduce the severity of subsequent idiopathic AP and the frequency of biliary pancreatitis.


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