Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 18  |  Issue : 1  |  Page : 18--22

Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?


Zaigham Abbas, Mustafa Qureshi, Saeed Hamid, Wasim Jafri 
 Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan

Correspondence Address:
Zaigham Abbas
Department of Medicine, The Aga Khan University Hospital, Karachi-74800
Pakistan

Background/Aim: Hepatitis D virus (HDV) superinfection in patients with chronic hepatitis B leads to accelerated liver injury, early cirrhosis, and decompensation. It may be speculated that hepatocellular carcinoma (HCC) may differ in these patients from hepatitis B virus (HBV) monoinfection. The aim of this study was to compare clinical aspects of hepatocellular carcinoma in patients of hepatitis D with HBV monoinfection. Patients and Methods: A total of 92 consecutive HCC cases seropositive for antibody against HDV antigen (HDV group) were compared with 92 HBsAg-positive and anti-HDV-negative cases (HBV group). Results: The features including sex, body mass index, presence of ascites, serum biochemistry, gross tumor appearance, child class, barcelona cancer liver clinic and okuda stages were not significantly different between the 2 groups. Decreased liver size was noticed more in cases of HDV compared with HBV group where the liver size was normal or increased (P=0.000). HDV patients had lower platelets (P=0.053) and larger varices on endoscopy (P=0.004). Multifocal tumors and elevated alpha-fetoprotein level >1000 IU/mL were more common in HBV group (P=0.040 and P= 0.061). TNM classification showed more stage III-IV disease in HBV group (P=0.000). Conclusion: Decreased liver size and indirect evidence of more severe portal hypertension and earlier TNM stage compared with HBV monoinfection indicate that HDV infection causes HCC in a different way, possibly indirectly by inducing inflammation and cirrhosis.


How to cite this article:
Abbas Z, Qureshi M, Hamid S, Jafri W. Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?.Saudi J Gastroenterol 2012;18:18-22


How to cite this URL:
Abbas Z, Qureshi M, Hamid S, Jafri W. Hepatocellular carcinoma in hepatitis D: Does it differ from hepatitis B monoinfection?. Saudi J Gastroenterol [serial online] 2012 [cited 2022 May 17 ];18:18-22
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2012;volume=18;issue=1;spage=18;epage=22;aulast=Abbas;type=0