Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 20  |  Issue : 2  |  Page : 134--138

Correlation of pretreatment hemoglobin and platelet counts with clinicopathological features in colorectal cancer in Saudi population


Eyad F Al-Saeed1, Mutahir A Tunio2, Omar Al-Obaid3, Maha Abdulla4, Alaa Al-Anazi5, Jumanah Al-Shanifi5, Leena Al-Ameer5, Tarfah Al-Obaidan5 
1 Consultant Radiation Oncology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
2 Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia
3 Consultant Colorectal Surgery, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
4 Colorectal Center, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
5 Medical Student, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Mutahir A Tunio
Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh - 59046
Saudi Arabia

Background/Aims: In Saudi Arabia, colorectal cancers (CRCs) are registered as the second most common cancers. However, no data has been reported about correlation of the severity of the anemia and pretreatment platelets level with clinicopathological features of CRCs. We aimed to evaluate the association between pretreatment hemoglobin and platelets level and the clinicopathological features of CRC patients in Saudi Arabia. Materials and Methods: Between September 2005 and November 2011, One hundred and fifty-four confirmed CRC patients underwent thorough physical examination, blood investigations, endoscopic ultrasonography (EUS), and computed tomography (CT) for staging before surgery. Findings of physical assessment, EUS, CT, and pathological specimens were correlated with pretreatment hemoglobin and platelets levels the Pearson-Kendall tau correlative coefficients. Results: The mean age of cohort was 56.6 years (range: 26-89). Left-sided CRC were predominant (97 patients; 63%). Mean size of primary tumor was 6 cms (1-18) SD ± 3.55. Mean values of hemoglobin, red blood cells, hematocrit, white blood cells, and platelets were 11.9 SD ± 2.3, 35.5 SD ± 5.7, 4.43 × 10 6 /mL SD ± 0.6, 7.67 10 6 /mL SD ± 2.44, and 343 × 10 3 /mL SD ± 164.4, respectively. Pretreatment hemoglobin was inversely correlated with primary tumor size (R: 0.71, R2: 1.55, P = 0.0001) and nodal status (R: 0.02, R2: 0.05, P = 0.01). Right-sided CRC had significantly low pretreatment hemoglobin levels ( P = 0.001). Interestingly, pretreatment thrombocytosis was seen only in right-sided CRC (P = 0.0001). Conclusion: Pretreatment anemia and thrombocytosis were found mainly in right-sided CRCs and advanced primary and nodal stages. Pretreatment hemoglobin and thrombocytosis can be considered as useful prognostic markers in CRC patients.


How to cite this article:
Al-Saeed EF, Tunio MA, Al-Obaid O, Abdulla M, Al-Anazi A, Al-Shanifi J, Al-Ameer L, Al-Obaidan T. Correlation of pretreatment hemoglobin and platelet counts with clinicopathological features in colorectal cancer in Saudi population.Saudi J Gastroenterol 2014;20:134-138


How to cite this URL:
Al-Saeed EF, Tunio MA, Al-Obaid O, Abdulla M, Al-Anazi A, Al-Shanifi J, Al-Ameer L, Al-Obaidan T. Correlation of pretreatment hemoglobin and platelet counts with clinicopathological features in colorectal cancer in Saudi population. Saudi J Gastroenterol [serial online] 2014 [cited 2023 Jan 27 ];20:134-138
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2014;volume=20;issue=2;spage=134;epage=138;aulast=Al-Saeed;type=0