Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 20  |  Issue : 5  |  Page : 297--303

Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats


Erkan Cure1, Medine C Cure2, Levent Tumkaya3, Yildiray Kalkan3, Ibrahim Aydin4, Aynur Kirbas2, Arif Yilmaz5, Suleyman Yuce1, Mehmet F Gokce6 
1 Department of Internal Medicine, Recep Tayyip Erdogan University, School of Medicine, Rize, Turkey
2 Department of Biochemistry, Recep Tayyip Erdogan University, School of Medicine, Rize, Turkey
3 Department of Histology and Embryology, Recep Tayyip Erdogan University, School of Medicine, Rize, Turkey
4 Department of Surgery, Recep Tayyip Erdogan University, School of Medicine, Rize, Turkey
5 Department of Gastroenterology, Recep Tayyip Erdogan University, School of Medicine, Rize, Turkey
6 Department of Physiology, Recep Tayyip Erdogan University, School of Medicine, Rize, Turkey

Correspondence Address:
Dr. Erkan Cure
Department of Internal Medicine, University of Recep Tayyip Erdogan, School of Medicine, Rize - 53100
Turkey

Background and Aim : Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes damage to lower extremities and many organs, especially liver. The antioxidant and tumor necrosis factor-alpha (TNF-α) suppression effects of topiramate (TPM) have been reported in several studies. We evaluated the potential protective effect of TPM on cellular damage in liver tissue during I/R injury. Materials and Methods : Thirty male Wistar albino rats were divided into three groups: Control, I/R, and I/R plus TPM (I/R + TPM) groups. Laparotomy without I/R injury was performed in the control group. After laparotomy, cross-ligation of infrarenal abdominal aorta was applied for 2 h in I/R groups that was followed by 2 h of reperfusion. TPM (100 mg/kg/day) was orally administrated to the animals in the I/R + TPM group for seven consecutive days before I/R procedure. Results : The I/R group«SQ»s TNF-α and interleukin-6 (IL-6) levels were significantly higher than those of the control (P = 0.010; P = 0.002) and I/R + TPM groups (P = 0.010; P = 0.002, respectively). Asymmetric dimethyl arginine (ADMA) levels of I/R group were higher than the control (P = 0.015) and I/R + TPM groups. I/R caused serious histopathological damage to liver tissue; however, TPM led to very low histopathological changes. Conclusion : Our data demonstrated that TPM treatment prominently decreases the severity of liver I/R injury. TPM pretreatment may have preventive effects on liver injury via I/R during intra-abdominal surgery.


How to cite this article:
Cure E, Cure MC, Tumkaya L, Kalkan Y, Aydin I, Kirbas A, Yilmaz A, Yuce S, Gokce MF. Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats.Saudi J Gastroenterol 2014;20:297-303


How to cite this URL:
Cure E, Cure MC, Tumkaya L, Kalkan Y, Aydin I, Kirbas A, Yilmaz A, Yuce S, Gokce MF. Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats. Saudi J Gastroenterol [serial online] 2014 [cited 2022 Sep 25 ];20:297-303
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2014;volume=20;issue=5;spage=297;epage=303;aulast=Cure;type=0