Saudi Journal of Gastroenterology

REVIEW ARTICLE
Year
: 2021  |  Volume : 27  |  Issue : 6  |  Page : 319--330

Nonalcoholic fatty liver disease: The role of quercetin and its therapeutic implications


Maria Sotiropoulou1, Ioannis Katsaros1, Michail Vailas1, Irene Lidoriki1, George V Papatheodoridis2, Nikolaos G Kostomitsopoulos3, Georgia Valsami4, Alexandra Tsaroucha5, Dimitrios Schizas1 
1 Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
2 Department of Gastroenterology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
3 Center of Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece
4 Department of Pharmacy, Laboratory of Biopharmaceutics-Pharmacokinetics, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece
5 Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

Correspondence Address:
Dr. Michail Vailas
Department of Surgery, Laikon General Hospital, 17 Agiou Thoma, Athens 11527
Greece

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting almost one-third of the general population and 75% of obese patients with type 2 diabetes. The aim of this article is to review the current evidence concerning the role of quercetin, a natural compound and flavonoid, and its possible therapeutic effects on this modern-day disease. Despite the fact that the exact pathophysiological mechanisms through which quercetin has a hepatoprotective effect on NAFLD are still not fully elucidated, this review clearly demonstrates that this flavonoid has potent antioxidative stress action and inhibitory effects on hepatocyte apoptosis, inflammation, and generation of reactive oxygen species, factors which are linked to the development of the disease. NAFLD is closely associated with increased dietary fat consumption, especially in Western countries. The hepatoprotective effect of quercetin against NAFLD merits serious consideration and further validation by future studies.


How to cite this article:
Sotiropoulou M, Katsaros I, Vailas M, Lidoriki I, Papatheodoridis GV, Kostomitsopoulos NG, Valsami G, Tsaroucha A, Schizas D. Nonalcoholic fatty liver disease: The role of quercetin and its therapeutic implications.Saudi J Gastroenterol 2021;27:319-330


How to cite this URL:
Sotiropoulou M, Katsaros I, Vailas M, Lidoriki I, Papatheodoridis GV, Kostomitsopoulos NG, Valsami G, Tsaroucha A, Schizas D. Nonalcoholic fatty liver disease: The role of quercetin and its therapeutic implications. Saudi J Gastroenterol [serial online] 2021 [cited 2021 Dec 4 ];27:319-330
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2021;volume=27;issue=6;spage=319;epage=330;aulast=Sotiropoulou;type=0